Novel Peptide Mimetic Inhibitors
of Hepatitis C Serine Protease Derived from Isomannide

Thalita G. Barros; Sergio Pinheiro; John S. Williamson; Amílcar Tanuri; Helena S. Pereira; Rodrigo M. Brindeiro; José B. A. Neto; Octávio A. C. Antunes; Estela M. F. Muri

doi:10.1055/s-0028-1083332

PAPER

Novel Peptide Mimetic Inhibitors of Hepatitis C Serine Protease Derived from Isomannide

Thalita G. Barros^a,b, Sergio Pinheiro^b, John S. Williamson^c, Amílcar Tanuri^d, Helena S. Pereira^d,e, Rodrigo M. Brindeiro^d, José B. A. Neto^d, Octávio A. C. Antunes^f, Estela M. F. Muri*^a
^a Faculdade de Farmácia, Universidade Federal Fluminense (UFF), Rua Mario Viana 523, Santa Rosa, Niterói, RJ 24241000, Brazil
Fax: +55(21)26299588; e-Mail: estelamuri@yahoo.com.br;
^b Instituto de Química, Campus do Valonguinho, UFF, Niterói, RJ 24020150, Brazil
^c School of Pharmacy, Department of Medicinal Chemistry, University of Mississippi, MS 38677, USA
^d Laboratório de Virologia Molecular, ICB, UFRJ, Rio de Janeiro, RJ 21941570, Brazil
^e Faculdade de Odontologia de Nova Friburgo, Universidade Federal Fluminense (FOUFF), Nova Friburgo, RJ 28625650, Brazil
^f Laboratório de catálise, Instituto de Química, UFRJ, Rio de Janeiro, RJ 21941909, Brazil

Abstract

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Abstract

Hepatitis C (HCV) infection is a cause of chronic liver disease such as cirrhosis, carcinoma, or liver failure, and the current therapy is effective in only 50% of patients. Serine proteases, which are present in HCV, are the most studied class of proteolytic enzymes, and are a primary target in the drug development field. In this paper, we describe the synthesis and biological studies of a novel class of peptide mimetic compounds as potential HCV serine protease inhibitors.

Key words

peptides - antiviral agent - fused-ring systems - isomannide - hepatitis C

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